Related Products of 1137-68-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1137-68-4, name is 2-(2-Pyridyl)benzimidazole. A new synthetic method of this compound is introduced below.
Potassium hydroxide 51 mmol and 2-pyridylbenzimidazole were added to the reaction flask10.2 mmol, and 20 ml of 1-butyl-3-methylimidazolium hexafluorophosphate (ionic liquid) was added. After the mixture was stirred for 5 min in advance, 8 ml of 1,6-dibromohexane was added and the reaction was stirred for 5 h. After the reaction is complete, extract three times with ether, combine the oil phases, and use rotationThe evaporator removes the solvent. The resulting crude product was separated by column chromatography. The volume ratio of the eluent was petroleum ether:ethyl acetate=A 3:1 mixed solution finally gave 2.2 g of a colorless oily liquid with a yield of 60%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1137-68-4, 2-(2-Pyridyl)benzimidazole, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing University of Posts and Telecommunications; Zhao Qiang; Yang Jiguang; Xu Wenjuan; Huang Wei; Liu Shujuan; Qin Yanyan; (26 pag.)CN106397488; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem