Electric Literature of 7471-05-8 ,Some common heterocyclic compound, 7471-05-8, molecular formula is C8H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure for dehydrogenation of imidazolines with NaIO4 catalyzed by [Mn(TPP)Cl]: All of the reactions were carried out at room temperature under air in a 25 mL flask equipped with a magnetic stirrer bar. A solution of NaIO4 (2 mmol) in H2O (10 mL) was added to a mixture of 2-imidazolines (1 mmol), [Mn(TPP)Cl] (0.05 mmol) in CH3CN (5 mL). The progress of reaction was monitored by TLC (eluent: EtOAc/MeOH 4:1). After the reaction was completed, water (30 mL) was added and the corresponding imidazoles were extracted with CH2Cl2 (2 x 20 mL). The imidazole derivatives were obtained after evaporation of solvent. IR and 1H NMR spectral data confirmed the identities of the products.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7471-05-8, 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kargar, Hadi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Nameni, Iman; Bioorganic and Medicinal Chemistry Letters; vol. 21; 7; (2011); p. 2146 – 2148;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem