Synthetic Route of 19755-53-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19755-53-4, name is 2-Bromo-3-nitropyridine. A new synthetic method of this compound is introduced below.
2. N-(4-TERT-BUTYL-PHENYL)-4- (3-NITRO-PYRIDIN-2-YL)-BERAZAMIDE Bubble nitrogen through a solution of 4-BORONO-N- (4-TERT-BUTYL-PHENYL)-BENZAMIDE (1.3 g, 4.37 mmol), 2-bromo-3-nitro-pyridine (0. 63 g, 3.12 mmol), 2M NA2CO3 (3.9 ml, 2.5 equivalents), in DME for 10 minutes. Add Pd (PPH3) 4 (144 mg) and bubble nitrogen through the solution for two additional minutes. Heat the reaction for 12 hours at 80C. Cool the reaction, concentrate, and partition between EtOAc and water. Dry the solution (Na2SO4) and concentrate under reduced pressure to give the crude product. Purify using chromatography (25% ethyl acetate/hexanes eluent) to give N- (4-tert-butyl-phenyl)-4- (3- nitro-pyridin-2-yl)-benzamide as a solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19755-53-4, 2-Bromo-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; NEUROGEN CORPORATION; WO2004/56774; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem