Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-4-methoxy-5-nitropyridine
A mixture of 2-chloro-4-methoxy-5-nitropyridine (208 mg, 1.10 mmol), ammonium chloride (295 mg, 5.52 mmol) and iron powder (246mg, 4.4immol) in ethanol (5mL) and water (0.5mL) was heated at 80 oC for 18 h. The mixture was cooled and filtered through a Celite cartridge and washed through with methanol. The combined filtrate and washing was evaporated, and the residue partitioned between DCM (10 mL)and water (10 mL), the organic phase was washed further with water (10 mL), and the aqueous washes were combined and extracted with DCM (3 x 5 mL). The organic extracts were combined and filtered through a hydrophobic fit, and the solvent was removed by evaporation to give the product as an off-white solid (155 mg, 89%). ?H NMR (400 MHz, CDC13): oe 7.73 (s, 1H); 6.71 (s, 1H); 3.90 (s, 3 H); 3.71 (s, 2H).
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; CHAMBERS, Mark; CHAN, Bryan K.; ESTRADA, Anthony; SWEENEY, Zachary Kevin; WO2013/79495; (2013); A1;,
Pyridine – Wikipedia,
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