Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5ClN2O3
Under nitrogen, Example 23B (70 mg, 0.42 mmol), 2-chloro-4-methoxy-5-nitropyridine (94 mg, 0.5 mmol), Pd2 (dba)3 (38 mg , 0.04 mmol), Xantphos (24 mg, 0.04 mmol) and cesium carbonate (271 mg, 0.83 mmol) in dioxane (5mL) were stirred at 90 deg.C for 12 hours. LCMS showed the reaction was complete. After the reaction mixture was diluted with water (40mL) (50mL × 2) and extracted with dichloromethane. The organic layer was washed with brine (30mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column (petroleum ether: ethyl acetate = 4: 1, 3: 1) to give the title compound (50mg, yield 37.5%) as a yellow oil.
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Reference:
Patent; Nanjing Mingde New Drug Research and Development Co. Ltd.; Qilu Pharmaceutical Co., Ltd.; Ding, Zhaozhong; Zhang, Minghui; Chen, Shuhui; Liu, Xile; Zhu, Yidong; Fan, Chuanwen; Zhao, Baoping; Zhang, Long; Chen, Dong; Yang, Yingying; Zheng, Qingmei; Zheng, Shansong; Wan, Haiwen; Hu, Jinqing; (93 pag.)CN105330698; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem