Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 905563-79-3, name is 2-Chloro-4-methoxynicotinaldehyde. A new synthetic method of this compound is introduced below., Quality Control of 2-Chloro-4-methoxynicotinaldehyde
(2) Synthesis of 2-chloro-4-methoxy-3-(2-methoxyvinyl)pyridine Under nitrogen atmosphere, 4.07g of (methoxymethyl) triphenylphosphonium chloride was suspended in 50ml of tetrahydrofuran, 1.37g of potassium tert-butoxide was added in an ice-cooling, which was stirred for 10 minutes. 1.02g of 2-chloro-4-methoxypyridine-3-carbaldehyde was dissolved in 20ml of tetrahydrofuran, which was added to reaction liquid, and was stirred for another 40 minutes. Water and diethyl ether were added to reaction liquid, and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The reaction liquid was concentrated under a reduced pressure after removal of drying agent by filtration. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate) to give 1.18g of the title compound as a mixture of the geometric isomers.
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Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1847535; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem