With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98197-88-7, name is 2-(Hydroxymethyl)-4-nitropyridine, molecular formula is C6H6N2O3, molecular weight is 154.12, as common compound, the synthetic route is as follows.SDS of cas: 98197-88-7
A 200-mL round-bottomed flask was charged with isopropanol (50 mL) and NaH (2.12 g, 53 57 mmol) and stirred at 0 C under inert atmosphere for 1 h. After, (4-nitropyridin-2- yl)methanol (1.0 g, 6.5 mmol) was added to the stirring reaction mixture. The resulting reaction mixture was refluxed for 20 h. After this period, the reaction mixture was cooled with an ice bath, quenched with saturated aqueous NHUCI and concentrated in vacuo. The resulting reside was extracted with EtOAc (3 >< 75 mL). The combined organic layers were dried over anhydrous NaaSC filtered, and concentrated in vacuo. The crude material purified by flash chromatography (60 to 100% EtOAc in hexanes) on silica gel (55 mL) to afford (4~isopropoxypyridin-2-yl)methano (242 mg, 22% yield) as a brown oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,98197-88-7, 2-(Hydroxymethyl)-4-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; KOIDE, Kazunori; BEIN, Kiflai; BRESSIN, Robert, Kruger; BURROWS, James, Proviano; GAMBINO, Adriana; LEIKAUF, George, D.; PHAM, Dianne; (80 pag.)WO2020/27905; (2020); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem