The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65515-39-1, name is 2-Methoxy-4,6-dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 65515-39-1
To a solution of 2-methoxy-4,6-dimethylnicotinonitrile (1.5 g, 9.25 mmol) in tetrahydrofuran (40 mL) was added lithium bis(trimethylsilyl)amide (10.17 mL, 10.17 mmol) at -78 C, and the mixture was stirred at -78 C for 1 hour. 3-Bromoprop-1-ene (0.880 mL, 10.17 mmol) was added and the mixture was stirred at -78 C for 1 hour and warmed to 0 C over 1 hour. The mixture was then stirred at 0 C for 3 hours. The reaction was quenched with saturated aqueous NH4Cl solution and extracted with EtOAc (3x). The combined organics were dried over Na2SO4 and concentrated. The residue was purified using reverse HPLC using Trilution software, with a phenomenex Gemini 5u CI 8(2) 100 A, AXIA 30×100 mm 5 micron, 10-minute run (30 mL/min, 40%ACN/H2O, 0.1% formic acid to 80% ACN/H2O, 0.1% formic acid) with UV detection at 254 nm to afford 4-(but-3-en-1-yl)-2-methoxy-6-methylnicotinonitrile (1.01 g, 54%) as a pale yellow oil. LC-MS(ES) m/z = 203 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 65515-39-1.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; MILLER, William Henry; ROMERIL, Stuart Paul; VERMA, Sharad Kumar; TIAN, Xinrong; WO2015/132765; (2015); A1;,
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