In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10592-27-5, name is 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. name: 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine
l,3-Dibromo-5,5-dimethylhydantoin (9.64 g) was added to a mixture of 2,3-dihydro- lH-pyrrolo[2,3-6]pyridine (8.1 g), 4-toluenesulphonic acid monohydrate (1.03 g) and methylene chloride (550 ml) and the resultant mixture was stirred at ambient temperature for 1 hour. The reaction solution was decanted from a black tar. The organic solution was washed with an 0.2M aqueous sodium thiosulphate solution (2 x 250 ml) and with brine, dried over magnesium sulphate and evaporated. There was thus obtained 5-bromo-2,3-dihydro- lH-pyrrolo[2,3-6]pyridine (4.05 g); 1H NMR Spectrum: (DMSOd6) 2.99 (t, 2H), 3.47-3.52 (m, 2H), 6.58 (s, IH), 7.38-7.39 (m, IH), 7.72 (t, IH). Mass Spectrum; M+H+ 199 and 201.
The synthetic route of 10592-27-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/135398; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem