Application of 86604-79-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 86604-79-7, name is 2,3,5-Trimethyl-4-nitropyridine 1-oxide. A new synthetic method of this compound is introduced below.
2,3,5-trimethyl-4-nitropyridine 1-oxide (850 g, 4.67 mol) was charged with water (400 g) and 36% concentrated hydrochloric acid (1.69 kg), and the resultant solution was heated to 70C. The solution was then charged with N,N-dimethylformamide (115 mL) and heated to 100C. Once the reaction had finished, the solution was cooled to 20C and then charged into a mixture of potassium carbonate (1.40 kg) and water (7 L). The resultant mixture was extracted with chloroform (1.0 L ¡Á 3), dried over sodium sulfate and then concentrated. The resultant crude product was stirred for 2 hours in a mixed solution of diisopropyl ether (500 mL) and n-hexane (1.0 L), and the resultant solution was then filtered with suction. The resultant wet substance was dried overnight under vacuum to obtain 666.4 g of the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,86604-79-7, 2,3,5-Trimethyl-4-nitropyridine 1-oxide, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1875911; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem