Application of 669066-89-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 669066-89-1, name is 3-Amino-5-bromopicolinamide. A new synthetic method of this compound is introduced below.
(b) 3-Amino-5-bromopicolinic acid. A mixture of 3-amino-5- bromopicolinamide (28.2 g, 0.13 mol) and concentrated HCl (361 inL) was heated at reflux for 12 hours. The reaction mixture was allowed to reach room temperature, and the solid which precipitated was filtered. The filter cake was dissolved in water, and the pH of the aqueous solution was adjusted to pH = 4 with saturated NaOAc, and extracted with EtOAc (3 x). The combined organic extracts were dried over anhydrous MgSO4, and filtered. The filtrate was evaporated under reduced pressure, and the residue dried in vacuo to afford the title compound as a solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,669066-89-1, 3-Amino-5-bromopicolinamide, and friends who are interested can also refer to it.
Reference:
Patent; AMGEN INC.; WO2008/76425; (2008); A1;,
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