Electric Literature of 81565-19-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81565-19-7, name is 3-Chloro-4-(trifluoromethyl)pyridine, molecular formula is C6H3ClF3N, molecular weight is 181.5429, as common compound, the synthetic route is as follows.
In a 1000 ml four-necked flask equipped with a thermometer and a dropping funnel, 33.3 g (0.314 mol) of sodium carbonate and 133.2 g of tap water were charged, and after stirring for 10 minutes, 120 ml of toluene was added, and aminoacetonitrile hydrochloride was 21.79 g (0.235). Mol), then the temperature is lowered to 10 C under stirring, and the dropwise addition of 4-(trifluoromethyl)nicotinyl chloride solution is started. The addition is completed in about 3 hours, the temperature is maintained at 10-15 C, and the addition is completed. After incubation at 30 C for 2 hours, the reaction was completed, filtered, and the product was washed with 30 ml of water to obtain a white solid product, N-cyanomethyl-4-(trifluoromethyl)nicotinamide.The purity was 99.8%, and the yield was 93.2% based on 4-(trifluoromethyl)nicotinic acid.
The chemical industry reduces the impact on the environment during synthesis 81565-19-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd.; Ni Zheng; (7 pag.)CN108892638; (2018); A;,
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