Reference of 6332-56-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6332-56-5, name is 3-Nitropyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
2-Hydroxy-3-nitro-pyridine (75 g, 0.535 mole) and 1400 ML of anhydrous tetrahydrofuran were stirred at 0 C. using a mechanical stirrer.. lithium bis(trimethylsilyl)amide (1.0 M solution in tetrahydrofuran, 683.5 ML) was slowly added over 30 minutes.. The deep brown reaction mixture was stirred for 30 additional minutes and then t-butyl bromoacetate (109.6 g, 0.561 mole) was slowly added over 30 minutes.. The reaction mixture was warmed to 25 C. overnight.. The organic solvents were removed under vacuum and the residue was dissolved in 2 liters of ethyl acetate and 500 ML of water.. The organic phase was dried with magnesium sulfate, filtered and evaporated under vacuum.. The residue was chromatographed on silica gel using a methylene chloride:ethanol gradient, 100:0 to 98:2, to yield 102.1 g (75 %) of the title compound as a yellow-orange solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6332-56-5, 3-Nitropyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Corvas International, Inc.; US6342504; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem