Adding a certain compound to certain chemical reactions, such as: 36953-37-4, 4-Bromopyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Bromopyridin-2(1H)-one, blongs to pyridine-derivatives compound. name: 4-Bromopyridin-2(1H)-one
Sodium chloro(difluoro)acetate (5.26 g, 34.5 mmol) and potassium carbonate (3.57 g, 25.8 mmol) were added to a solution of 4-bromopyridin-2(1 /-/)-one (3.00 g, 17.2 mmol) in /V,/V-dimethylformamide (30 mL), and the reaction mixture was stirred at 95 C for 2 hours. Water (100 mL) was added, and the resulting mixture was extracted with ethyl acetate (3 x 50 mL). The combined organic layers were washed sequentially with water (200 mL) and with saturated aqueous sodium chloride solution (150 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Silica gel chromatography (Eluent: 15: 1 petroleum ether / ethyl acetate) afforded the product as a pale yellow oil. Yield: 1.5 g, 6.7 mmol, 39%. 1H NMR (400 MHz, CDCI3) delta 8.04 (d, J=5.5 Hz, 1H), 7.44 (t, JHF=72.6 HZ, 1H), 7.27 (dd, J=5.4, 1.6 Hz, 1H), 7.12 (br d, J=1.5 Hz, 1H).
The synthetic route of 36953-37-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; BECK, Elizabeth Mary; BRODNEY, Michael Aaron; BROWN, Matthew Frank; BUTLER, Christopher Ryan; GILBERT, Adam Matthew; LACHAPELLE, Erik Alphie; MCALLISTER, Laura Ann; UCCELLO, Daniel Paul; ZHANG, Lei; (140 pag.)WO2018/234953; (2018); A1;,
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