Synthetic Route of 38923-08-9, Adding some certain compound to certain chemical reactions, such as: 38923-08-9, name is Ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate,molecular formula is C10H9N3O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38923-08-9.
A suspension of ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate (20) (20 g, 85 mmol) in MeOH (200 ml) was cooled to 0 C, 12M hydrogen chloride (70 ml, 850 mmol) was added drop wise followed by portion wise addition of zinc (22.3 g, 340 mmol). The reaction mixture was stirred for 30 minutes.Next, MeOH (140 ml) was added and the reaction was quenched with concentrated NH3(15 equiv.) and filtered. The solid residue was washed with MeOH (2 x 25 ml). The filtratewas concentrated and re-suspended in CHC13 (700 ml), H20 (300 ml) and concentrated NH3(300 ml, 35% solution). This mixture was stirred until everything was dissolved. The layerswere separated and the water layer was extracted once with CHC13. The organic layers werecombined, washed with a saturated aqueous NaC1 solution (50 ml), dried over MgSO4,filtered and concentrated in vacuo to yield ethyl 6-aminoimidazo [1 ,2-a]pyridine-2-carboxylate (21) (11.8 g, 68%) as a grey/green solid. UPLC-MS confirmed that the desired product was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38923-08-9, Ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNTHON BIOPHARMACEUTICALS B.V.; HUIJBRGTS, Tijl; ELGERSMA, Ronald Christiaan; BEUSKER, Patrick Henry; JOOSTEN, Johannes Albertus Frederikus; COUMANS, Rudy Gerardus Elisabeth; SPIJKER, Henri Johannes; MENGE, Wiro; DE GROOT, Franciscus Mariuns Hendrikus; WO2015/185142; (2015); A1;,
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