The common heterocyclic compound, 462-08-8, name is Pyridin-3-amine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 462-08-8
In the three bottle,3-aminopyridine (20.0 g, 212.5 mmol),4-Dimethylaminopyridine (4-DMAP) (0.3 g, 2.1 mmol)And pyridine (33.6 g, 425.0 mmol) dissolved in anhydrous dichloromethane (200 mL),Pivaloyl chloride (28.2 g, 233.7 mmol) was slowly added dropwise in an ice bath.0 C reaction 2h.After the reaction was completed, the reaction solution was poured into ice water, quenched with 1N hydrochloric acid, extracted with dichloromethane (250 mL¡Á3), and the organic phase was collected and washed with saturated brine (200 mL¡Á1).The solvent was evaporated under reduced pressure to give 3-pivalamidopyridine (36.2 g).Yield 95.5%.
The synthetic route of 462-08-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guizhou University; Liu Li; Huang Zhuyan; Yue Yi; (8 pag.)CN107382839; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem