Adding a certain compound to certain chemical reactions, such as: 4966-90-9, 4-Hydroxy-6-methyl-3-nitropyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 4966-90-9, blongs to pyridine-derivatives compound. Product Details of 4966-90-9
Step A: A stirred solution of 4-hydroxy-6-methyl-3-nitro-2-pyridone (2.24 g, 13.2 mmol) in POCl3 (13 mL) was refluxed overnight. The excess POCl3 was removed under vacuum and ice was added to the black residue. The resulting slurry was carefully neutralized (pH 7) by addition of conc. NH4OH. The resulting slurry was poured through filter paper, washing the solid with cold water. The solid was dried under vacuum at 50 C. overnight to give crude 2,4-dichloro-6-methyl-3-nitropyridine, 2.12 g (78%) as black crystals.
The synthetic route of 4966-90-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Vanderbilt University; Fesik, Steve; Waterson, Alex; Burns, Michael; Sun, Qi; Phan, Jason; Salovich, James M.; Abbott, Jason R.; Little, Andrew; (159 pag.)US10501421; (2019); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem