With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1446237-40-6, name is 5-Bromo-1,4-dimethyl-3-nitropyridin-2(1H)-one, molecular formula is C7H7BrN2O3, molecular weight is 247.05, as common compound, the synthetic route is as follows.category: pyridine-derivatives
To a stirred mixture of NEUCI (17.3 g, 323.42 mmol, 10.0 equiv) in EEO/EtOH (1 /1 , 400 ml_) was added 5-bromo-1 , 4-dimethyl-3-nitro-1 , 2-dihydropyridin-2-one (8.0 g, 32.38 mmol, 1 .0 equiv) and Fe (18.1 g, 324.1 1 mmol, 10.0 equiv) at room temperature. The mixture was stirred at rt. for 2 hours, the solid was filtered off. The filtrate was diluted with water (100 ml_) and extracted with ethyl acetate (200 ml_ x 2). The organic layers were combined and washed with saturated NaCI (aq.), dried over with anhydrous Na2SC>4. After filtration, the filtrate was concentrated under reduced pressure. This resulted in 6.56 g (93%) 3-amino-5-bromo-1 ,4-dimethyl- pyridin-2(1 H)-one as a red solid that was used directly without further purification. LCMS (ESI) m/z: [M+H]+ = 217.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1446237-40-6, 5-Bromo-1,4-dimethyl-3-nitropyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; FOGHORN THERAPEUTICS INC.; ZHOU, Qianhe; BOCKER, Michael; MILLAN, David, Simon; CHAN, Ho, Man; SOARES, Luis; NETHERTON, Matthew, Russell; RUPPEL, Sabine, K.; YANG, Zhaoxia; LOWE, Jason, T.; BRUCELLE, Francois; (220 pag.)WO2019/152440; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem