Synthetic Route of 1241752-31-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1241752-31-7, name is 5-Bromo-2-ethoxy-3-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 5-bromo-2-ethoxy-3-methoxy-pyridine (1 .70 g, 7.33 mmol) in N,Ndimethylformamide (10 mL) was added zinc cyanide (860 mg, 7.33 mmol, 464 iL), and tetrakis(triphenylphosphine)palladium(0) (847 mg, 733 imol, 0.10 eq), the mixture was degassed with nitrogen for three times. The resulting mixture was stirred at 110 00 for 12 h under nitrogen atmosphereand then poured into water (30 mL). The mixture was then extracted with dichloromethane (50 mL x 3). The organic extracts were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to provide the crude product purified by chromatography (silica, petroleum ether ethyl acetate 50:1 Rt 0.6). The title compound, 6-ethoxy-5-methoxy-pyridine-3-carbonitrile was isolated as a white solid (820 mg, 4.60 mmol, 63 %) 1H NMR (400MHz, METHANOL-d4) O 8.08 (d,J1.8 Hz, 1H), 7.49(d, J1.8 Hz, 1H), 4.48 (q, J7.1 Hz, 2H), 3.92 -3.88 (m, 3H), 1.42(t, J7.1 Hz, 3H)
According to the analysis of related databases, 1241752-31-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; YUMANITY THERAPEUTICS; LUCAS, Matthew; LE BOURDONNEC, Bertrand; WRONA, Iwona; PANDYA, Bhaumik; TIVITMAHAISOON, Parcharee; OZBOYA, Kerem; VINCENT, Benjamin; TARDIFF, Daniel; PIOTROWSKI, Jeff; SOLIS, Eric; SCANNEVIN, Robert; CHUNG, Chee-Yeun; ARON, Rebecca; RHODES, Kenneth; (489 pag.)WO2018/81167; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem