Adding a certain compound to certain chemical reactions, such as: 82454-61-3, 5-Ethynylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Ethynylpyridin-2-amine, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Ethynylpyridin-2-amine
Copper(I) iodide (6.279 mg, 0.033 mmol) was added to a stirred mixture of intermediate 1-8 (913 mg, 3.297 mmol), 5-ethynyl-2-pyridinamine (779 mg, 6.594 mmol), Et3N (1.4 mL, 9.891 mmol), PdCl2(PPh3)2 (46 mg, 0.0659 mmol) and PPh3 (17.295 mg, 0.0659 mmol) in DMF (7.659 mL). The mixture was purged with nitrogen for 5 min and then it was stirred at 90 ¡ãC for 16h. The mixture was diluted with water and extracted with EtOAc. The organic layer was separated, dried (Na2S04), filtered and the solvents concentrated in vacuo. The crude product was purified by flash column chromatography (silica; MeOH in DCM 0/100 to 6/94). The desired fractions were collected and the solvents concentrated in vacuo. The residue was precipitated with DIPE and filtered to yield intermediate compound 1-24 (581 mg, 66percent) as a yellow solid
The synthetic route of 82454-61-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANDRES-GIL, Jose, Ignacio; VAN GOOL, Michiel, Luc, Maria; TRABANCO-SUAREZ, Andres, Avelino; DE LUCAS OLIVARES, Ana, Isabel; ALONSO-DE DIEGO, Sergio-Alvar; DELGADO-GONZALEZ, Oscar; (79 pag.)WO2016/16381; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem