In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 884494-82-0, name is 5-Fluoro-2-methoxynicotinic acid, the common compound, a new synthetic route is introduced below. Safety of 5-Fluoro-2-methoxynicotinic acid
5-Fluoro-2-methoxy-pyridine-3-carboxylic acid (166 mg, 0.97 mmol) and 6-[4-[(lS)- 2,2,2-trifluoro-l-methyl-ethyl]-l,2,4-triazol-3-yl]pyridin-2-amine (250 mg, 0.97 mmol) were dissolved in triethylamine (1.35 mL, 9.72 mmol) and propylphosphonic anhydride (> 50 wt % in EtOAc, 1.0 mL). The reaction was heated at 80 C for 3 h. The reaction was cooled to rt, quenched by addition of MeOH (5 mL) and stirred for 1 h. The resulting solid was filtered and dried in vacuo to give the title compound (247 mg, 62%) as a white solid. ‘H NMR (400 MHz, CD3OD) d 9.02 (s, 1H), 8.38 (dd, 7=1.63, 7.40 Hz, 1H), 8.27 (d, 7=3.26 Hz, 1H), 8.14 – 8.21 (m, 1H), 7.97 – 8.04 (m, 2H), 6.89 (quin, 7=7.22 Hz, 1H), 4.15 (s, 3H), 1.89 (d, 7=7.28 Hz, 2H), 1.86-1.91 (m, 1H). MS (ESI): 411.1 [M + H]+.
The synthetic route of 884494-82-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOGEN MA INC.; GONZALEZ LOPEZ DE TURISO, Felix; DECHANTSREITER, Michael; XIN, Zhili; JONES, John, H.; HIMMELBAUER, Martin; (0 pag.)WO2020/6031; (2020); A1;,
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