New learning discoveries about 55-22-1

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 55-22-1 is helpful to your research. Formula: C6H5NO2.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 55-22-1, Name is Isonicotinic acid, SMILES is OC(=O)C1=CC=NC=C1, belongs to pyridine-derivatives compound. In a document, author is La Piana, Luana, introduce the new discover, Formula: C6H5NO2.

Polypyridine ligands as potential metallo-beta-lactamase inhibitors

Bacteria have developed multiple resistance mechanisms against the most used antibiotics. In particular, zinc-dependent metallo-beta-lactamase producing bacteria are a growing threat, and therapeutic options are limited. Zinc chelators have recently been investigated as metallo-beta-lactamase inhibitors, as they are often able to restore carbapenem susceptibility. We synthesized polypyridyl ligands, N,N’-bis(2-pyridylmethyl)-ethylenediamine, N, N,N’-tris(2-pyridylmethyl)-ethylenediamine, N,N’-bis(2-pyridylmethyl)-ethylenediamine-N-acetic acid (N,N,N’-tris(2-pyridylmethyl)-ethylenediamine-N’-acetic acid, which can form zinc(II) complexes. We tested their ability to restore the antibiotic activity of meropenem against three clinical strains isolated from blood and metallo-beta-lactamase producers (Klebsiella pneumoniae, Enterobacter cloacae, and Stenotrophomonas maltophilia). We functionalized N,N,N’-tris(2-pyridylmethyl)-ethylenediamine with D-alanyl-D-alanyl-D-alanine methyl ester with the aim to increase bacterial uptake. We observed synergistic activity of four polypyridyl ligands with meropenem against all tested isolates, while the combination N,N’-bis(2-pyridylmethyl)-ethylenediamine and meropenem was synergistic only against New Delhi and Verona integron-encoded metallo-beta-lactamase-producing bacteria. All synergistic interactions restored the antimicrobial activity of meropenem, providing a significant decrease of minimal inhibitory concentration value (by 8- to 128-fold). We also studied toxicity of the ligands in two normal peripheral blood lymphocytes.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 55-22-1 is helpful to your research. Formula: C6H5NO2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem