Reference of 57963-08-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57963-08-3, name is 5,6-Dimethylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.
DIPEA (0.257 g, 1.99 mmol) was added to a suspension of intermediate Z48 (0.20 g, 0.66 mmol), 5,6-dimethylpyridin-2-amine (0.097 g, 0.80 mmol) and HATU (0.38 g, 1.00 mmol) in DCM (15 mL) at 0 C. The reaction was allowed to warm to rt and was stirred for 18 h before being quenched with water, extracted with DCM (2 x 40 mL), washed with brine and dried over anhydrous Na2S04. Solvents were removed in vacuo and the crude product was purified by flash column chromatography (10% ethyl acetate in hexane) to afford intermediate Y21 (0.091 g, 0.22 mmol, 34%) as a white solid. 1H NMR (DMSO-d6, 400 MHz) delta: 10.86 (1H, s), 7.95-7.93 (1H, d, J= 8.4 Hz), 7.89-7.88 (1H, d, J= 2.0 Hz), 7.81-7.79 (1H, dd, J= 8.4 Hz, 2.0 Hz), 7.56-7.54 (1H, d, J= 8.4 Hz), 7.47-7.45 (1H, d, J= 8.0 Hz), 2.35 (3H, s), 2.22 (3H, s), 1.36 (9H, s).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 57963-08-3, 5,6-Dimethylpyridin-2-amine.
Reference:
Patent; H. LUNDBECK A/S; MALTAS, Philip James; WATSON, Stephen; LANGGARD, Morten; DAVID, Laurent; WO2014/114779; (2014); A1;,
Pyridine – Wikipedia,
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