Electric Literature of 56057-19-3, Adding some certain compound to certain chemical reactions, such as: 56057-19-3, name is 6-Chloro-5-nitro-2-picoline,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56057-19-3.
EXAMPLE P1 Preparation of 7-chloro-5-methyl-1H-pyrrolo[2,3-c]pyridine (P1.1) Vinylmagnesium bromide solution (1 M in THF, 111 mL, 111 mmol) was added dropwise at -78 C. to a solution of 2-chloro-3-nitro-6-picoline (6.19 g, 35.2 mmol) in THF (200 mL). The dry ice cooling bath was replaced by an ice/NaCl cooling bath, and the reaction mixture was allowed to reach RT over 18 h, then the reaction mixture was carefully treated with 20% aq. ammonium chloride solution (210 mL). The reaction mixture was extracted with ethyl acetate, the organic layer was dried (MgSO4), and evaporated. Chromatography of the residue (SiO2, heptane/ethyl acetate gradient) afforded the title compound (2.58 g, 44%). Orange solid, MS (EI) 166.1 (100, M+).
According to the analysis of related databases, 56057-19-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Pflieger, Philippe; Scalone, Michelangelo; US2007/185154; (2007); A1;,
Pyridine – Wikipedia,
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