Application of 582303-10-4 ,Some common heterocyclic compound, 582303-10-4, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of this alcohol compound (32.2 g, 235 mmol) in 144 ml toluene and 120 ml CHCl3 was added dropwise to a solution of SOCl2 (18.8 ml, 259 mmol) in 24 ml toluene, all the while maintaining the internal temperature between 23 and 35. After the end of the addition the reaction mixture was vigorously stirred at 35 for 1.5 h and water pump vacuum was applied until the solvent was completely evaporated. The brown precipitate was resuspended in toluene, rapidly filtered off and washed three times with toluene. Drying in the desiccator (aspirator vacuum) gave 33.8 g (176 mmol, 75%) of 5-(chloromethyl)-2,6-dimethylpyridine hydrochloride as a light brown solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,582303-10-4, its application will become more common.
Reference:
Patent; Phan, Hieu Trung; Nguyen, Lan Mong; Azoulay, Raymond; Diep, Vinh Van; Eschenhof, Harald; Niesor, Eric Joseph; Bentzen, Craig Leigh; Ife, Robert John; US2005/124586; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem