Adding a certain compound to certain chemical reactions, such as: 59105-50-9, (5-Bromopyridin-3-yl)(phenyl)methanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H8BrNO, blongs to pyridine-derivatives compound. Formula: C12H8BrNO
PdCl2(PPh3)2 (148 mg, 0.21 mmol) and CuI (120.6 mg, 0.63 mmol) were added to asolution of (5-bromopyridin-3-yl)(phenyl)methanone (1.1 g, 4.22 mmol) in Et3N (10 mL)under N2, and the resulting mixture was stirred for 30 min. Then ethynylbenzene (516 mg, 5.1mmol) was added dropwise and the reaction mixture was stirred overnight at roomtemperature, followed by filtration over Celite and evaporation under vacuum. Purificationby column chromatography on silica gel afforded the desired product.To the crude product in a mixture of THF (12 mL) and MeOH (12 mL) was added 10% Pdon carbon (80 mg), and the atmosphere was changed to H2 (2.5 bar). The resulting mixturewas stirred in a Parr hydrogenation apparatus overnight at room temperature, followed byfiltration over Celite and evaporation under vacuum. Purification by column chromatographyon silica gel afforded the desired product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,59105-50-9, (5-Bromopyridin-3-yl)(phenyl)methanone, and friends who are interested can also refer to it.
Reference:
Article; Fu, Yun; Sun, Jian; Molecules; vol. 24; 3; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem