Application of 159307-02-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.159307-02-5, name is 6-Acetylpicolinonitrile, molecular formula is C8H6N2O, molecular weight is 146.15, as common compound, the synthetic route is as follows.
Compound 4a:to 100 ml by adding three-necked bottle of 2-cyano-6-acetyl-pyridine (2.00g, 13 . 68mmol), 2,6-diisopropyl aniline (2.91g, 16 . 42mmol), the toluene sulphonic acid monohydrate (130 mg, 0 . 68mmol), solvent toluene and 35 ml, reflux device installed, heating reaction refluxing 48h. Cooling to room temperature, vacuum concentration, rapid column chromatography purification (ethyl acetate: petroleum ether = 1:30), to get the yellow solid (4.05g, 97%),
Statistics shows that 159307-02-5 is playing an increasingly important role. we look forward to future research findings about 6-Acetylpicolinonitrile.
Reference:
Patent; Shanghai Institute of Organic Chemistry; Huang, Zheng; Zuo, Ziqing; Zhang, Lei; (50 pag.)CN105294667; (2016); A;,
Pyridine – Wikipedia,
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