Related Products of 116355-18-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 116355-18-1 as follows.
The compound of example 146 (10 g, 47.4 mmol) was treated with pyridin-3-ylboronic acid (6.41 g, 52.1 mmol) in the presence of [1 ,1 ‘-bis(diphenylphosphino)- ferrocene]dichloropalladium(ll) complex with dichloromethane (0.77 g, 0.948 mmol) and sodium carbonate (7.53 g, 71 .1 mmol) according to the procedure for the preparation of the compound of example 2 to afford the title compound. Yield: 8.2 g (83 %); 1H NMR (DMSO-de, 300 MHz): delta 2.2 (s, 3H, CH3), 7.49-7.57 (m, 3H, Ar), 7.70-7.84 (d, 1 H, J=8.1 Hz Ar), 7.90-7.92 (d, 1 H, J=7.5 Hz, Ar), 8.5 (s, 1 H, Ar), 8.6 (s, 1 H, Ar), 8.9 (s, 1 H, Ar); MS (ES+): m/e 210.1 (M+1 ).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116355-18-1, its application will become more common.
Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; GHOSH, Usha; MORE, Tulsidas; KULKARNI, Mahesh; BAJAJ, Komal; BURUDKAR, Sandeep; RIZVI, Zejah; WO2014/80241; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem