Synthetic Route of 7477-10-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7477-10-3 as follows.
To a suspension of 49.0 g (0.27 mol) 6-hydroxy-5-nitro-nicouenic acid in thionyl chloride (240 mi) are added 2 ml of DMF. This mixture is stirred at 60C until the evolution of gaz has ended. Then it is stirred at 80C for further 18 h. Residual thionyl chloride is removed under vacuo and the resulting residue is coevaporated three times with toluene. Subsequently this reaction mixture is dissolved in dichloromethane (100 mi) and cooled to 0C before methanol (55.5 ml) is dropwise added. The precipitated solid is filtered off and dried under vacuo at 50C to give 27.6 g (13.7 mmol/52 %) of the title compound as a light yellow solid with a melting point of 78C (dichloromethane/methanol).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7477-10-3, its application will become more common.
Reference:
Patent; ALTANA PHARMA AG; WO2005/77947; (2005); A1;,
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