Related Products of 6937-03-7 , The common heterocyclic compound, 6937-03-7, name is Methyl 2-aminoisonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add in the reaction tube0.2 mmol of methyl 2-aminopyridine-4-carboxylate,0.2 mmol of beta-nitrostyrene,lOmol% (0.02 mmol) Ce (OTf) 3, 1.5 ml toluene,After stirring at 120 C for 10 minutes, the heating and stirring were stopped, and the mixture was cooled to room temperature.The crude product is obtained by distillation under reduced pressure and purified by column chromatography.The target product was obtained, and the column chromatography eluent used was a mixture of petroleum ether and ethyl acetate (V:V = 5:1).The yield was 53%. The hydrogen spectrum and carbon spectrum of the product obtained in this example are shown in Fig. 3.The carbon spectrum of the obtained product is shown in Fig. 4.
The synthetic route of 6937-03-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gannan Normal University; Chen Zhengwang; Ye Min; Zhou Zhonggao; (17 pag.)CN108395399; (2018); A;,
Pyridine – Wikipedia,
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