Application of 74784-70-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74784-70-6 as follows.
To a de-gassed mixture of 3- [3- (trifluoromethyl) pyridin-2-yl] pyrido [2,3-b] pyrazin-8- amine (72 mg, 0.25 MMOL), cesium carbonate (162 mg, 0.5 mmol), 2-amino-trifluoromethyl pyridine (45 mg, 0.25 mmol) in dioxane (5 mL) under nitrogen, add PD2DBA3 (11 mg) and xantphos (7 MG). Stir the mixture AT 100C for 3 hours, cool, add water (10 mL) and extract with EtOAc. Dry over NA2SO4, concentrate under vacuum. Purify by chromatography eluting with DICHLOROMETHANE/METHANOL/AMMONIUM hydroxide mixture to give the title compound. MS 437 (M + 1).’H NMR 6 (CDCI3) 9.42 (1H, s), 9.28 (1H, s), 9.11 (1H, d), 8.95 (1H, d), 8. 90 (IH, d), 8.72 (1H, s), 8.25 (1H, d), 7.89 (1H, d), 7.61 (1H, dd), 7.13 (1H, d).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74784-70-6, its application will become more common.
Reference:
Patent; NEUROGEN CORPORATION; WO2005/7652; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem