Application of 870997-85-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 870997-85-6, name is 3-Amino-5-bromopyridine-2-carboxylic Acid, molecular formula is C6H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1: 3-Amino-5-(4-trifluoromethyl-phenylsulfanyl)-pyridine-2-carboxylic acid: [00275] A solution of 3-amino-5-bromopyridine-2-carboxylic acid (Int 1, 3.78 g, 17.4 mmol), 4- trifluoromethyl-benzenethiol (CAS: 825-83-2, 4.1 g, 21 mmol) and DBU (2.60 mL, 17.4 mmol) was prepared in DMA (15 mL). This mixture was heated at 140 C for 45 minutes in a microwave reactor. Next, the mixture was diluted with a mixture of 1% AcOH in water. A suspension was obtained that was subsequently filtered. The collected solid was washed with a 1% AcOH/water mixture followed by washing with petroleum ether. After drying in a vacuum oven, a powder was obtained that was used without additional purification.
According to the analysis of related databases, 870997-85-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBVIE S.A.R.L.; GALAPAGOS NV; ALTENBACH, Robert, J.; COWART, Marlon, D.; DE MUNCK, Tom, Roger Lisette; DROPSIT MONTOVERT, Sebastien Jean, Jacques Cedric; GFESSER, Gregory, A.; KELGTERMANS, Hans; MARTINA, Sebastien, Laurent Xavier; VAN DER PLAS, Steven, Emiel; WANG, Xueqing; (300 pag.)WO2016/193812; (2016); A1;,
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