In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 89466-18-2
6-bromo-2-methoxy-3-amine (1.02g, WO2011068211 pamphlet) In acetonitrile (20mL) solution,At 0 , 37% aqueous solution of formaldehyde (1.22g)And the mixture was stirred for 10 minutes. The reaction mixture was cooled to room temperature, sodium triacetoxyborohydride (3.18g) was added,The reaction was stirred overnight at the same temperature.Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate,After filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexaEmissions: ethyl acetate = 9: 1 ? 4: 1) was purified by,6-bromo-2-methoxy -N, N-dimethyl-3-amine and 6-bromo-2-methoxy -N- methyl-pyridin-3-amine 2 was obtained 1 mixture (475 mg).
The synthetic route of 89466-18-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; NISSAN CHEMICAL INDUSTRIES LIMITED; KURODA, SHOICHI; USHIKI, YASUNOBU; KAWAGUCHI, TAKANORI; FUSEGI, KEIKO; BOHNO, MASAHIRO; IMAI, YUDAI; UNEUCHI, FUMITO; IWAKIRI, KANAKO; TANAKA, HIROAKI; BOHNO, AYAKO; CHONAN, TOMOMICHI; ITOH, SHIN; OTA, HIROFUMI; ISHIYAMA, SEISHI; OKADA, TAKUYA; SASAKO, SHIGETADA; MONMA, SOUICHI; NIWA, MARIE; OKADA, TAKUMI; (289 pag.)JP2015/231988; (2015); A;,
Pyridine – Wikipedia,
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