Electric Literature of 89488-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one, molecular formula is C6H6BrNO, molecular weight is 188.0219, as common compound, the synthetic route is as follows.
(0592) To a solution of 5-bromo-2-hydroxy-3-methyl pyridine (376 mg, 2.00 mmol) in toluene (15 mL) were added Ag2C03 (827 mg, 3.00 mmol) and benzyl bromide ( 13 mg, 3.00 mmol), and the mixture was stirred at 40 C for 2 h. The insoluble material was filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column (eluent: dichloromethane/ methanol, 0-20%) to yield light yellow solid (436 mg, 78%). 1H NMR (400 MHz, chloroform-c ) delta 8.08 – 8.02 (m, 1H), 7.51 (m, 1H), 7.49 – 7.41 (m, 2H), 7.43- 7.28 (m, 3H), 5.38 (s, 2H), 2.22 (s, 3H).
Statistics shows that 89488-30-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-3-methylpyridin-2(1H)-one.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; YIN, Hang Hubert; ZHANG, Shuting; HU, Zhenyi; (114 pag.)WO2019/89648; (2019); A1;,
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