A common compound: 97483-77-7, name is 5-Bromopicolinonitrile,molecular formula is C6H3BrN2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 97483-77-7
lOg of 2-cyano-5-bromopyridine prepared in the Preparation example 5 was dissolved in 100ml of dimethylformamide, 5.33g of sodiumazide, and 4.4g of ammoniumchloride were added to the solution at room temperature, and the solution was stirred at the temperature of 110C for 3 hours for reaction. The reaction mixture was added with water and then was extracted with ethyl acetate. The organic layer, thus separated, was washed with brine, dehydrated, filtrated and concentrated in vacuo thereby to obtain 10. 5g of the title compound. Yield 85%.
With the rapid development of chemical substances, we look forward to future research findings about 97483-77-7.
Reference:
Patent; DONG-A PHARM.CO.,LTD.; WO2005/58886; (2005); A1;,
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