An article 4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis WOS:000457961800001 published article about MONOAMINE-OXIDASE-B; HIGH-POTENCY; IN-VITRO; MAO; SCAFFOLD; DESIGN; AGENTS; IDENTIFICATION in [Secci, Daniela; Guglielmi, Paolo; D’Ascenzio, Melissa; Chimenti, Paola] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, Rome, Italy; [Carradori, Simone] G DAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Sch Pharm, Pharmaceut Chem, Potchefstroom, South Africa; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa; [Bagetta, Donatella; Alcaro, Stefano; Ortuso, Francesco] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Catanzaro, Italy; [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey; [D’Ascenzio, Melissa] Univ Dundee, Sch Life Sci, DArcy Thompson Unit, Dundee DD1 4HN, Scotland in 2019.0, Cited 51.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure-activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties.
Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 3-Pyridinecarboxaldehyde
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem