The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H8N2O
Add 5.0g (0.034mol) to a 500mL single-mouth bottle4,6-dimethyl-3-cyanopyrimidin-2-one,250mL of methanol, not fully soluble,25mL 25% ammonia water,About 5.0g of nickel, replaced by argon three times,The hydrogen was replaced three times, and the temperature was raised to 50 C. After 11 h of reaction, the TLC reaction was complete.Stop the reaction and filter the solution through diatomaceous earth.The filtrate was evaporated to dryness to give 6.3 g, m.Dissolve the product with methanol,Placed in an ice salt bath,20mL of 4N hydrochloric acid ethanol solution was added dropwise with stirring.After the drop,After stirring for 1 h in an ice bath, a large amount of white solid was precipitated, which was filtered with suction to give a white solid.Wash twice with ethanol, suction filtration,Dry to give 5.0 g of a white solid.The yield was 96.9%.
With the rapid development of chemical substances, we look forward to future research findings about 769-28-8.
Reference:
Patent; Shenyang Pharmaceutical University; Chen Guoliang; Wang Lihui; Zhou Qifan; Du Fangyu; Dong Xiaoyu; Yang Jingyu; Wu Chunfu; (48 pag.)CN109320499; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem