Related Products of 58584-86-4, Adding some certain compound to certain chemical reactions, such as: 58584-86-4, name is Ethyl 2,6-dichloronicotinate,molecular formula is C8H7Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58584-86-4.
Substitution of NaOEt (5.8 g, 1.5 eq) with ethyl 2,6-dichloronicotinate (12.5 g, 56.8 mmol) in CH2Cl2 was performed (Reference: US2005/0288299A1) by slow addition of the base solid to the bis-chloro ester solution at 0 C. and stirred for 3 h with the cooling, then overnight from 0 C. to r.t. More CH2Cl2 and water were added, separated, dried and evaporated giving a liquid (11.62 g) that crystallized slowly overnight. The solid was recrystallized from dry-ice-cooling pentane affording the desired ethyl 6-chloro-2-ethoxynicotinate as white crystals (9.45 g, 41.15 mmol, yield 72.4%). (0725) M.p. 33-35 C. 1H NMR (300 MHz, DMSO-d6): delta 8.13 (d, J=8.1 Hz, 1H), 8.16 (d, J=8.1 Hz, 1H), 4.34 (q, J=7.2 Hz, 2H), 4.24 (q, J=7.2 Hz, 2H), 1.31 (t, J=7.2 Hz, 3H) and 1.27 (t, J=7.2 Hz, 3H) ppm.
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Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; AKAMA, Tsutomu; US2015/291629; (2015); A1;,
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