The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103041-38-9, name is Ethyl 3-(pyridin-2-ylamino)propanoate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C10H14N2O2
EXAMPLE 1 Preparation of Ethyl 3-[[4-(methylamino)-3-nitrobenzoyl](pyridin-2-yl)amino]-propanoate (II) 100 g of compound I was dissolved in 1 L of dichloromethane under nitrogen atmosphere and cooled to 0-5 C. Thionyl chloride was added to the reaction mixture for 1 h and the reaction mixture was boiled to reflux. Maintained the reaction mass under the same temperature for 5-6 h. After completion of the reaction, excess thionyl chloride was removed by co-distillation with dichloromethane and finally the solvent was completely removed under vacuum. The acid chloride was then dissolved in dichloromethane under an inert atmosphere and triethyl amine was added to the reaction mixture. To the reaction mixture was added slowly a solution of ethyl-3-(pyridine-2-ylamino) propanoate in dichloromethane. The reaction mixture was maintained at the same temperature for another 6-12 h. After completion of the reaction, the reaction mass was diluted water and extracted the product with dichloromethane. The combined organic layers were separated and dried over anhydrous sodium sulphate. The solvent was distilled off under vacuum and the product was purified by hexane. Yield: 80%, HPLC: >98%
With the rapid development of chemical substances, we look forward to future research findings about 103041-38-9.
Reference:
Patent; Biophore India Pharmeuticals PVT. Ltd.; Pullagurla, Manik Reddy; Rangisetty, Jagadeesh Babu; Nandakumar, Mecheril Valsan; (8 pag.)US2015/246900; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem