New learning discoveries about Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64119-42-2, Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 64119-42-2, Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 64119-42-2, blongs to pyridine-derivatives compound. SDS of cas: 64119-42-2

(c) ethyl 5-cyano-2-methyl-6- [4-(5-phenyl-4H-l,2,4-triazol-3-yl)piperidin-l- yl]nicotinateThe crude 4-(5-phenyl-4H- 1 ,2,4-triazolr3-yl)piperidine and ethyl 6-chloro-5-cyano-2- methylnicotinate (178 mg) were dissolved in EtOH (9 ml) and DIPEA was added. The reaction mixture was heated to 120 0C for 5 min using microwave single node heating. LCMS showed complete conversion of starting material and one by product (1,3,4- oxadiazole). NaHCO3 (aq) was added and the mixture was extracted with dichloromethane (x3). The combined organic layer was run through a phase separator and evaporated. The crude product was purified by prepHPLC [Kromasil C8, Gradient: 40 to 80 % (CH3CN/0. IM NH-iAcCXaq), pH = 7)] to afford ethyl 5-cyano-2-methyl-6-[4-(5-phenyl- 4H-l,2,4-triazot3-yl)rhoiperidin-l-yl]nicotinate. Yield 49 mg (14.8% over 3 steps). (The 1,3,4-oxadiazole was not isolated).1HNMR (500MHz, DMSOd6): 1.31 (3H, t, J=7.1Hz), 1.82-1.90 (2H, m), 2.10-2.15 (2H, m), 2.65 (3H, s), 3.15-3.26 (IH, m), 3.35-3.40 (2H, m), 4.25 (2H, q, J=7.1), 4.59-4.65 (2H, m), 7.39-7.48 (3H, m), 7.96-7.99 (2H, m), 8.34 (IH, s), 13.85 (IH, br s), MS m/z: 417 (MH-I), 415 (M-I).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64119-42-2, Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; WO2008/4942; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem