As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64951-08-2, name is Imidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 64951-08-2
To a solution of imidazo[l,2-a]pyridine-2-carboxylic acid (262 mg, 1.62 mmol) in N,N-dimethylformamide (5 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU, 616 mg, 1.62 mmol), ethyldiisopropylamine (697mg, 5.40 mmol). The resulting mixture was stirred at room (0804) temperature for 30 min. Ethyl 2-((2S,4tf)-4-((((9H-fluoren-9-yl) (0805) methoxy)carbonyl)amino)pyrrolidin-2-yl)thiazole-4-carboxylate (500 mg, 1.08 mmol) was added. The mixture was stirred at room temperature for 12 h. The mixture was concentrated, dissolved in ethyl acetate, washed with 1 N lithium chloride. The organic layer was concentrated to give ethyl 2-((2S,4 ?)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-l-(imidazo[l,2- a]pyridine-2-carbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate as a brown solid. MS(ESI) m/z 608.2 [M + H]+.
With the rapid development of chemical substances, we look forward to future research findings about 64951-08-2.
Reference:
Patent; DYAX CORP.; TRAVINS, Jeremy; MILLER, Thomas; PAPAIOANNOU, Nikolaos; (199 pag.)WO2019/28362; (2019); A1;,
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