New learning discoveries about Pyridine-2,3,4-triamine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52559-11-2, Pyridine-2,3,4-triamine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52559-11-2, name is Pyridine-2,3,4-triamine, molecular formula is C5H8N4, molecular weight is 124.14, as common compound, the synthetic route is as follows.Safety of Pyridine-2,3,4-triamine

Dissolve 2,3, 4-triaminopyridine (2.5 mmol) in water (20 mL). Add NAHCO3 (0.63 g, 7.5 mmol), dioxane (10 ML), AND 2-BROMO-1-(3-TRIRLUOROMETHYL-PYRIDIN-2-YL)-ETHANONE hydrobromide (0.5 g) and stir at 100C for 2 hours. Cool the mixture and extract with EtOAc (4 X 10 mL). Wash the combined organic extracts with brine and dry over NA2S04. Purify the residue by preparative HPLC to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52559-11-2, Pyridine-2,3,4-triamine, and friends who are interested can also refer to it.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7652; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem