Electric Literature of 490-11-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 490-11-9, name is Pyridine-3,4-dicarboxylicacid. A new synthetic method of this compound is introduced below.
Pyridine-3,4-dicarboxylic acid 42.1 (20 g, 121 mmol) was dissolved in methanol (400 ml)then concentrated sulfuric acid (12.9 ml, 242 mmol) was added and the mixture was stirredat reflux for 3 days. The volatiles were removed and the liquid poured carefully into saturatedsodium carbonate. The pH was adjusted to 7 with sodium carbonate then extracted threetimes with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered andevaporated to provide compound 42.2 (15.3 g, 65%) as an oil. 1H NMR (CDCI3, 300 MHz)O 3.95 (5, 6H), 7.50 (d, 1 H), 8.83 (d, 1 H), 9.06 (5, 1H). UPLC (CSH 2-50%) 0.60(196 [M+H]).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,490-11-9, Pyridine-3,4-dicarboxylicacid, and friends who are interested can also refer to it.
Reference:
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem