New learning discoveries about Synthetic Route of 13959-02-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13959-02-9, its application will become more common.

Synthetic Route of 13959-02-9 ,Some common heterocyclic compound, 13959-02-9, molecular formula is C6H4BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate AB: 3-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyI]isonicotinic acid3-bromoisonicotinic acid (730 mg, 3.61 mmol) and Cuprous Bromide (31 mg, 0.22 mmol) was suspended in an excess of diethyl malonate (30 ml). Sodium hydride (631 mg, 26.3 mmol, 55% in oil) was added in portions under argon. After addition the mixture was stirred for 2 hrs at 8O0C. The mixture was diluted with H2O and washed with TBDME (3 x 30 ml). The aqueous phase was acidified to pH 4 using cone. HCl and extracted with TBDME (3 x 30 ml). The combined organic layers (from 2nd extraction) were dried over Na2SO4 and evporated. The crude product was recrystallized from TBDME and Heptane affording 668 mg (66%) the title compound as a green solid. EPO APCI-MS m/z: 282.1 [MH+]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13959-02-9, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2007/30061; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem