Synthetic Route of 1083057-12-8, Adding some certain compound to certain chemical reactions, such as: 1083057-12-8, name is tert-Butyl 3-(3-methylpyridin-2-yl)benzoate,molecular formula is C17H19NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1083057-12-8.
Synthesis of 2-(3-(terf-butoxycarbonyl)phenyl)-3-methylpyridine-l-oxide (compound 5). urea-hydrogen peroxide phthalic anhydride EtOAc, water tBu[00261] Compound 4 (1.0 eq) is dissolved in EtOAc (6 vol). Water (0. 3 vol) is added followed by urea-hydrogen peroxide (3 eq). The phthalic anhydride (3 eq) is added portion-wise as a solid to maintain the temperature in the reactor below 45 0C. After completion of phthalic anhydride addition, the mixture is heated to 45 0C. After stirring for an additional 4 hours, the heat is turned off. 10% w/w aqueous Na2Stheta3 (1.5 eq) is added via addition funnel. After completion of Na2Stheta3 addition, the mixture is stirred for an additional 30 minutes and the layers separated. The organic layer is stirred and 10% w/w aq. Na2Ctheta3 (2 eq) is added. After stirring for 30 minutes, the layers are allowed to separate. The organic phase is washed 13% w/v aq NaCl. The organic phase is then filtered and concentrated to afford crude compound 5 (95%) that is used directly in the next step.
According to the analysis of related databases, 1083057-12-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2009/76142; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem