Adding a certain compound to certain chemical reactions, such as: 144657-66-9, tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 144657-66-9, blongs to pyridine-derivatives compound. SDS of cas: 144657-66-9
To a solution of 1-(tert-butoxycarbonyl)-3-formyl-7-azaindole (2.5g, 10.2 mmol) in 16 mL EtOH was added NaBH4 (115mg, 3.05 mmol). The reaction was stirred at ambient temperature for 4h, concentrated and triturated with IN NaOH. The basic solution was extracted with ether and ethylacetate. The organics were washed with water and brine, then dried over Na2S04, filtered and concentrated. The filtrate was concentrated and purified by silica gel chromatography (50% ethylacetate/hexanes) to give tert-butyl 3-(hydroxymethyl)-lH- pyrrolo[2,3-b]pyridine-l-carboxylate (44%). LCMS [M-tert-Bu]+ = 191.1.
The synthetic route of 144657-66-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn, J.; EGBERTSON, Melissa; BRNARDIC, Edward; JONES, Kristen; SANDERS, John, M.; HENZE, Darrell, A.; WO2013/176970; (2013); A1;,
Pyridine – Wikipedia,
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