With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, molecular weight is 278.3501, as common compound, the synthetic route is as follows.name: tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate
To a stirring solution OF CYCLOPENTYL- (4, 6-DICHLORO- [1, 3,5] triazin-2-yl) – amine (0.60g, 2.57 mmol) prepared as in Example 14A above in 5 ML OF acetonitrile was added 4- (5-AMINO-PYRIDIN-2-YL PIPERAZINE-1-CARBOXYLIC acid tert- butyl ester (0.72g, 2.6 mmol) and triethylamine (0.36 mL, 2.6 mmol). The mixture was stirred at ambient temperature. After 20 minutes, solids formed. The solids were filtered off and washed several times with acetonitrile. The solids were dried in a vacuum oven for 1.5 hours at 60C. Purification was accomplished via silica column chromotography in 7: 1 dichloromethane/acetone. The desired fractions were collected and concentrated in vacuo to afford N- Cyclopentyl-N’, N”-BIS- (6-PIPERAZIN-1-YL-PYRIDIN-3-YL)-1, 3,5-triazine-2, 4,6- triamine (Compound B) as a brown foam/solid (0.234g, 19%). Ms 517.3 ; Mp >290.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,119285-07-3, tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/65378; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem