As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85838-94-4, name is tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate, molecular formula is C10H17NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 85838-94-4
To a solution of N-Boc-1,2,3,6-tetrahydropyridine (3.63 g, 21.0 mmol) in 40 niL of dichloromethane was added 3-chloroperoxybenzoic acid (2.75 g, 15.0 mmol). The reaction was stirred at room temperature for 4 h, then washed 3x with saturated aqueous potassium carbonate and once with brine. The solution was dried over sodium sulfate, filtered, and concentrated in vacuo to provide crude fert-butyl 7-oxa-3-azabicyclo[4,1.0]heptane-3-carboxylate that gave a proton NMR spectra consistent with theory.
With the rapid development of chemical substances, we look forward to future research findings about 85838-94-4.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.; WO2011/25851; (2011); A1;,
Pyridine – Wikipedia,
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