COA of Formula: C6H4N2In 2022, Hethcox, J. Caleb;Sifri, Renee J. published 《Air-Tolerant Nickel-Catalyzed Cyanation of (Hetero)aryl Halides Enabled by Polymethylhydrosiloxane, a Green Reductant》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:
An air-tolerant nickel-catalyzed cyanation of aryl bromides ArBr (Ar = 3,5-difluorophenyl, 2-naphthyl, pyridin-3-yl, etc.) is reported. The reaction uses a NiCl2/Xantphos catalyst in combination with substoichiometric quantities of zinc cyanide and polymethylhydrosiloxane. This silane is a green, homogeneous alternative to the traditional, insoluble solid reductant zinc and renders the reaction tolerant to air. The reaction can be performed under an air atm., obviating the need for degassing, a glovebox, or Schlenk techniques. The reaction scope is broad, proceeding in good yields with a variety of (hetero)arenes. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.COA of Formula: C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.