COA of Formula: C6H4N2In 2022, Puzari, Amlan;Borah, Debajit;Das, Pankaj published 《Binuclear Pd(II) complexes with multidentate Schiff base ligands: synthesis, catalysis, and antibacterial properties》. 《Monatshefte fuer Chemie》published the findings. The article contains the following contents:
Abstract: Three new binuclear palladium(II) complexes with multidentate Schiff base ligands were synthesized and characterized by FTIR, UV-visible, 1H-NMR, ESI-MS, and CHN anal. The complexes were successfully applied as catalysts for hydration of nitriles to amides. Using one of the complexes, a wide range of aryl/heteroaryl nitriles were efficiently converted to corresponding amides in moderate-to-excellent yields with low catalyst loading (0.8 mol%). In addition, the complexes were also tested for antibacterial activity against two gram-pos. and two gram-neg. bacteria using Kirby Bauer’s disk diffusion method. However, to the authors’ surprise, among the three complexes, only one complex showed growth inhibitory effect against gram-pos. bacteria, Bacillus subtilis, for which min. inhibitory concentration (MIC) is 30μg cm-3. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2